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granzyme B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Caspase (5) COX (1) Fluorescent Dye (1) Interleukin Related (1)
By Research Areas:	Cancer (6) Inflammation/Immunology (3)

8

Inhibitors & Agonists

3

Fluorescent Dye

10

Peptides

1

Natural
Products

6

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Type

HY-P1169

Ac-IETD-AFC

Fluorescent Dyes/Probes

Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .

N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide Ac-IEPD-pNA	Fluorescent Dyes/Probes
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide (Ac-IEPD-pNA) is a granzyme B substrate that allows accurate measurement of granzyme B activity .

Ac-IETD-AMC	Fluorescent Dyes/Probes
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .

Cat. No.	Product Name	Target	Research Area

HY-P1169

Ac-IETD-AFC

Caspase Others

Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .

N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide Ac-IEPD-pNA	Peptides	Cancer
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide (Ac-IEPD-pNA) is a granzyme B substrate that allows accurate measurement of granzyme B activity .

HY-P10149

Ac-IEPD-CHO

Peptides Cancer

Ac-IEPD-CHO is a granzyme B inhibitor and can be used in cancer research .

Ac-IETD-AMC	Fluorescent Dye	Others
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .

HY-P4453

Boc-Ala-Ala-Asp-pNA

Caspase Cancer

Boc-Ala-Ala-Asp-pNA is a chromogenic substrate of granzyme B. Boc-Ala-Ala-Asp-pNA can be used to test functional activity of granzyme B .
HY-P1092

Ac-IEPD-AFC

Peptides Inflammation/Immunology

Ac-IEPD-AFC is a substrate of Granzyme B .
HY-P10004

Z-Ala-Ala-Asp-CMK

Z-AAD-CMK
Caspase Inflammation/Immunology

Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor .

Z-IETD-FMK 35+ Cited Publications Z-IE(OMe)TD(OMe)-FMK	Caspase	Cancer
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor . Z-IETD-FMK is also a granzyme B inhibitor .

Z-IETD-pNA Z-Ile-Glu-Thr-Asp-pNA	Caspase	Cancer
Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) is a colorimetric caspase-8 and granzyme B substrate. Z-IETD-pNA is hydrlyzed by caspase 8 to generate pNA .

Ac-IETD-CHO	Apoptosis	Cancer
Ac-?IETD-?CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac-?IETD-?CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac-?IETD-?CHO also inhibits cytotoxic T lymphocytes induced cell death .

Species:	Human (1) Mouse (5)
Tag:	His (4) Tag Free (2) B2M (1)
Source:	HEK293 (4) CHO (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	Granzyme B/GZMB Protein, Human (HEK293, His) granzyme B; CTLA-1; CCP1; Fragmentin-2; Gzmb	Human	HEK293
	Granzyme B (GZMB) is a cytosolic protease abundant in cytotoxic T-cells and natural killer cells, pivotal for immune defense. Delivered into target cells, GZMB activates caspase-independent pyroptosis by cleaving gasdermin-E (GSDME). This triggers pyroptosis, leading to target cell death. GZMB exhibits substrate specificity for aspartate residue cleavage and contributes to an activation cascade of caspases (3, 9, 10), impacting apoptosis execution. Involved in bacterial infection response, GZMB cleaves and activates caspase-7, promoting plasma membrane repair. Its multifaceted activities underscore its crucial role in immune responses and cellular defense. Granzyme B/GZMB Protein, Human (HEK293, His) is the recombinant human-derived Granzyme B/GZMB protein, expressed by HEK293, with C-His labeled tag. The total length of Granzyme B/GZMB Protein, Human (HEK293, His) is 247 a.a., with molecular weight of 35-40 kDa.

	Granzyme B/GZMB Protein, Mouse (CHO) rMugranzyme B; CTLA-1; CCP1; Fragmentin-2; Gzmb	Mouse	CHO
	Granzyme B/GZMB Protein, Mouse (CHO) plays essential roles in apoptosis and is involved in inducing inflammation by stimulating cytokine release and is also involved in extracellular matrix remodeling.

	Granzyme B/GZMB Protein, Mouse (HEK293, His) rMugranzyme B/GZMB, His; granzyme B(G; H); CTLA-1; Cytotoxic cell protease 1; CCP1; Fragmentin-2; Gzmb; Ctla-1; Ctla1	Mouse	HEK293
	Granzyme B/GZMB Protein, found in cytotoxic T-cells and NK-cells, activates caspase-independent pyroptosis and cleaves gasdermin-E (GSDME), inducing target cell death. It also participates in caspase activation cascade, promoting apoptosis and plasma membrane repair during bacterial infection. Granzyme B/GZMB Protein, Mouse (HEK293, His) is the recombinant mouse-derived Granzyme B/GZMB protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Granzyme B/GZMB Protein, Mouse (HEK293, His) is 229 a.a., with molecular weight of ~35.0 kDa.

	Granzyme B/GZMB Protein, Mouse (HEK293) rMugranzyme B; CTLA-1; CCP1; Fragmentin-2; Gzmb	Mouse	HEK293
	Granzyme B/GZMB Protein, Mouse (HEK293) plays essential roles in apoptosis and is involved in inducing inflammation by stimulating cytokine release and is also involved in extracellular matrix remodeling.

	Granzyme B/GZMB Protein, Mouse (HEK293, C-His) rMugranzyme B/GZMB, His; granzyme B(G; H); CTLA-1; Cytotoxic cell protease 1; CCP1; Fragmentin-2; Gzmb; Ctla-1; Ctla1	Mouse	HEK293
	Granzyme B/GZMB Protein, found in cytotoxic T-cells and NK-cells, activates caspase-independent pyroptosis and cleaves gasdermin-E (GSDME), inducing target cell death. It also participates in caspase activation cascade, promoting apoptosis and plasma membrane repair during bacterial infection. Granzyme B/GZMB Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived Granzyme B/GZMB protein, expressed by HEK293, with C-6*His labeled tag. The total length of Granzyme B/GZMB Protein, Mouse (HEK293, C-His) is 229 a.a., with molecular weight of ~35.0 kDa.

	*GZMA/Granzyme* A Protein, Mouse (His-B2M)** Gzma; Ctla-3; Ctla3; Mtsp-1; granzyme A; EC 3.4.21.78; Autocrine thymic lymphoma granzyme-like serine protease; CTLA-3; Fragmentin-1; T cell-specific serine protease 1; TSP-1	Mouse	E. coli
	GZMA/Granzyme A, abundant in cytotoxic T-cells and natural killer cells, crucially induces caspase-independent pyroptosis upon delivery into target cells. With substrate specificity for lysine or arginine residues, GZMA cleaves APEX1 and nucleosome assembly protein SET, disrupting their activities. This multifunctional protein plays a significant role in diverse cellular processes during immune responses. GZMA/Granzyme A Protein, Mouse (His-B2M) is the recombinant mouse-derived GZMA/Granzyme A protein, expressed by E. coli, with N-6*His, N-B2M labeled tag. The total length of GZMA/Granzyme A Protein, Mouse (His-B2M) is 232 a.a., with molecular weight of ~39.6 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P81581

Granzyme B Antibody (YA1326)

CGL1, CSPB, CTLA1,GRB
IHC-P Human

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